| First Author | Tu GF | Year | 1992 |
| Journal | Am J Physiol | Volume | 263 |
| Issue | 1 Pt 2 | Pages | R195-200 |
| PubMed ID | 1636787 | Mgi Jnum | J:1512 |
| Mgi Id | MGI:50039 | Doi | 10.1152/ajpregu.1992.263.1.R195 |
| Citation | Tu GF, et al. (1992) Strong conservation of the expression of cystatin C gene in choroid plexus. Am J Physiol 263(1 Pt 2):R195-200 |
| abstractText | The expression of the cystatin C gene was studied by Northern analysis of RNA isolated from the choroid plexus, other brain tissues, and liver from 11 mammalian and 4 avian species. The probe used for hybridization was cystatin C cDNA isolated previously from a rat choroid plexus cDNA library. Strong conservation of the expression of the cystatin C gene in choroid plexus was suggested by the observation of substantial levels of cystatin C mRNA in choroid plexus RNA from all mammalian and avian species studied. In contrast, levels of cystatin C mRNA in total liver RNA varied widely for mammalian as well as for avian species. It was concluded that the synthesis of cystatin C in choroid plexus has probably been conserved since the stage of the stem reptiles, the common ancestors of mammals and birds. The cystatin C gene was also found to be expressed early in ontogeny, as indicated by the observation of similar cystatin C mRNA levels in choroid plexus RNA from newly hatched and adult chickens. |
