| First Author | Tessarollo L | Year | 1992 |
| Journal | Development | Volume | 115 |
| Issue | 1 | Pages | 11-20 |
| PubMed ID | 1638975 | Mgi Jnum | J:1111 |
| Mgi Id | MGI:49643 | Doi | 10.1242/dev.115.1.11 |
| Citation | Tessarollo L, et al. (1992) c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development. Development 115(1):11-20 |
| abstractText | The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit ros-specific RNA using sensitive techniques such as RNAase protection and in situ hybridization. The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine. The data provide evidence for a role of c-ros in the obligate cell-cell interactions that characterize the morphogenic induction and proliferation of epithelial cells in the kidney, intestine and lung. The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions. |
