| First Author | Vidard L | Year | 1992 |
| Journal | Eur J Immunol | Volume | 22 |
| Issue | 8 | Pages | 2165-8 |
| PubMed ID | 1379188 | Mgi Jnum | J:2268 |
| Mgi Id | MGI:50792 | Doi | 10.1002/eji.1830220831 |
| Citation | Vidard L, et al. (1992) Processing and presentation of ovalbumin in mice genetically selected for antibody response. Eur J Immunol 22(8):2165-8 |
| abstractText | Lines of mice selected for high or low antibody production to sheep red blood cells (H-I and L-I) were studied for their ability to process and present ovalbumin to a panel of 12 T-T hybridomas in two different H-2 haplotypes. When H-I and L-I spleen cells were used as antigen-presenting cells, no difference could be observed in the peptide generation by these mice compared to H-2-compatible B.10.Q and B.10.S spleen cells, respectively. Neither normal splenic L-I B-cells nor L-I thioglycolate-induced peritoneal macrophages were defective at presenting native ovalbumin, to six and eight different I-As-restricted T-T hybrids, respectively. Altogether, these results differ from previous findings which had indicated a deficiency in the processing and presentation of antigen by the low line, L-I. |
