| First Author | Habets GG | Year | 1992 |
| Journal | Cytogenet Cell Genet | Volume | 60 |
| Issue | 3-4 | Pages | 200-5 |
| PubMed ID | 1505215 | Mgi Jnum | J:2049 |
| Mgi Id | MGI:50573 | Doi | 10.1159/000133336 |
| Citation | Habets GG, et al. (1992) Sublocalization of an invasion-inducing locus and other genes on human chromosome 7. Cytogenet Cell Genet 60(3-4):200-5 |
| abstractText | By somatic cell fusion studies between noninvasive mouse T-lymphoma cells and invasive human activated normal T-cells we have previously shown that the genetic information responsible for the induction of invasive and metastatic potential in interspecies T-cell hybrids is located on human chromosome 7. Apparently, genes derived from normal activated T-cells are dominantly expressed in the hybrids and control the invasive and, as a consequence, metastatic potential of these T-lymphoma cells. To sublocalize the invasion-inducing locus on chromosome 7 we have generated hybrids that harbor only specific regions of human chromosome 7 with or without a small fragment of human chromosome 21. Analysis of these hybrids revealed that the invasion-inducing locus maps to 7p12----cen. The human DNA complement of the hybrids was confirmed by Southern blot analysis using a large panel of chromosome 7-specific DNA probes. Several of these genes could be further sublocalized. These included: ARAF2 to 7p12----cen, D7S21 to 7pter----p12, ACTB to 7p15----p12, EGFR to 7p12, MDH2 to 7cen----q22, and PDGFA to 7pter----p15. |
