| First Author | Morita Y | Year | 1992 |
| Journal | Biochem Biophys Res Commun | Volume | 188 |
| Issue | 1 | Pages | 8-15 |
| PubMed ID | 1417871 | Mgi Jnum | J:2805 |
| Mgi Id | MGI:51326 | Doi | 10.1016/0006-291x(92)92342-u |
| Citation | Morita Y, et al. (1992) Expression and possible function of glucose transporter protein GLUT1 during preimplantation mouse development from oocytes to blastocysts. Biochem Biophys Res Commun 188(1):8-15 |
| abstractText | A micro-Western analysis method both sensitive and quantitative enough to analyze oocytes and embryos is developed. GLUT1 protein is present in mouse oocytes and preimplantation embryos and levels are increased by fertilization and with time in ensuing embryonic development; the levels were 20-fold greater in blastocysts than in unfertilized oocytes. Similar increases were observed in glucose uptake by oocytes and embryos, suggesting that they may depend on GLUT1 expression. These results suggest that GLUT1 expression may explain a switch in substrate preference of the embryo from pyruvate to glucose during preimplantation development. |
