| First Author | Zerubavel-Weiss R | Year | 1992 |
| Journal | J Autoimmun | Volume | 5 |
| Issue | 5 | Pages | 617-27 |
| PubMed ID | 1418298 | Mgi Jnum | J:2889 |
| Mgi Id | MGI:51409 | Doi | 10.1016/0896-8411(92)90158-m |
| Citation | Zerubavel-Weiss R, et al. (1992) Autoimmune thyroiditis (EAT) in genetically resistant mice mediated by a T cell line. J Autoimmun 5(5):617-27 |
| abstractText | Experimental autoimmune thyroiditis (EAT) can be induced in genetically susceptible strains of mice by immunization to mouse thyroglobulin (Tg). EAT also can be produced by administration of anti-mouse Tg T cell lines and clones. Previously we were able to raise virulent anti-Tg T cell lines from mice genetically susceptible to EAT. These virulent lines, upon attenuation, were able to vaccinate the susceptible mice against EAT. We now report the isolation of a virulent T cell line from C57BL/6 mice genetically resistant to EAT. The T cell line and its clones recognize a Tg epitope cross-reactive between mouse and bovine Tg. Unexpectedly, the virulent anti-Tg line attenuated in various ways failed to vaccinate C57BL/6 mice against EAT mediated by the line itself. These results shed some light on the regulation of autoimmunity. |
