| First Author | Sieburth D | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 1 | Pages | 59-62 |
| PubMed ID | 1358798 | Mgi Jnum | J:2176 |
| Mgi Id | MGI:50700 | Doi | 10.1016/s0888-7543(05)80283-6 |
| Citation | Sieburth D, et al. (1992) Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 14(1):59-62 |
| abstractText | IL12 (formerly NKSF or CLMF) is a unique cytokine composed of two unrelated disulfide-linked subunits. The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF. The chromosomal localization of these two subunits was determined by PCR analysis of DNA from rodent-human hybrids. More refined mapping was obtained by PCR analysis of hybrids containing translocation chromosomes and for p40, by analysis of radiation hybrids. The subunits map to different chromosomes: p40 (IL12B) to 5q31-q33 and p35 (IL12A) to 3p12-3q13.2. |
