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Publication : Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes.

First Author  Fietz MJ Year  1992
Journal  J Invest Dermatol Volume  99
Issue  5 Pages  542-4
PubMed ID  1431214 Mgi Jnum  J:3141
Mgi Id  MGI:51656 Doi  10.1111/1523-1747.ep12667301
Citation  Fietz MJ, et al. (1992) Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes. J Invest Dermatol 99(5):542-4
abstractText  The chromosomal location of the gene encoding the human hair follicle protein trichohyalin has been determined by in situ hybridization. The human gene has been localized to the region 1q21.1-1q23 (probably 1q21.3) using a sheep trichohyalin cDNA probe. The genes encoding three other epithelial proteins, namely, profilaggrin, involucrin, and loricrin, are also located in the same region of chromosome 1, which, together with their similar gene and protein structures, suggests that the four proteins form a novel superfamily of epithelial structural proteins.
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