| First Author | Penschow JD | Year | 1992 |
| Journal | Mol Cell Endocrinol | Volume | 88 |
| Issue | 1-3 | Pages | 23-30 |
| PubMed ID | 1334010 | Mgi Jnum | J:2808 |
| Mgi Id | MGI:51329 | Doi | 10.1016/0303-7207(92)90005-q |
| Citation | Penschow JD, et al. (1992) Sites of glandular kallikrein gene expression in fetal mice. Mol Cell Endocrinol 88(1-3):23-30 |
| abstractText | As part of an ongoing study of the cell-specific expression of glandular kallikrein genes in mice, we have investigated cellular sites of expression of the renal/pancreatic kallikrein gene, mGK-6, during fetal life. Expression of alpha I and beta-subunit genes of Na+K+ATPase and bradykinin binding were used as an indication of the functional maturity of the fetal epithelial tubules in which mGK-6 expression was identified. mGK-6 mRNA was first observed at embryonic day 16 (E16) in the submandibular main duct, then at E18 in the sub-lingual main duct, at E19 in renal tubules and at E19 in ducts of the nasal glands. All of these ducts contained detectable epithelial Na+K+ATPase mRNAs from an earlier gestational age than mGK-6 mRNA, suggesting their capacity for electrolyte transport. Bradykinin binding was evident in renal tubules at E18. This study established that renal/pancreatic kallikrein is synthesized in fetal epithelial tubules which are mature functionally. |
