| First Author | Elson CJ | Year | 1992 |
| Journal | Autoimmunity | Volume | 13 |
| Issue | 4 | Pages | 327-31 |
| PubMed ID | 1472643 | Mgi Jnum | J:11896 |
| Mgi Id | MGI:60166 | Doi | 10.3109/08916939209112342 |
| Citation | Elson CJ, et al. (1992) Mediators of joint swelling and damage in rheumatoid arthritis and pristane induced arthritis. Autoimmunity 13(4):327-31 |
| abstractText | Joint swelling and tenderness in rheumatoid arthritis (RA) probably result from IgG aggregates activating complement with the consequent attraction of polymorphonuclear leucocytes (PMNs) and the liberation of their granule enzymes such as kininogenases. By contrast IL-1 and TNF are the major stimulants of cartilage and bone loss although other agents contribute. The fundamental drive for the production of these mediators is unknown but a role for heat shock proteins is suggested from work on pristane induced arthritis. |
