| First Author | Rosnet O | Year | 1993 |
| Journal | Oncogene | Volume | 8 |
| Issue | 1 | Pages | 173-9 |
| PubMed ID | 8380915 | Mgi Jnum | J:3709 |
| Mgi Id | MGI:52218 | Citation | Rosnet O, et al. (1993) Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse. Oncogene 8(1):173-9 |
| abstractText | Receptor-type tyrosine kinases (RTK) with five or seven immunoglobulin-like domains in their extracellular region are encoded by genes grouped in clusters. In human, two such clusters have been individualized, in chromosomal regions 4q11-q12 and 5q33-qter respectively. We define here a third cluster located on chromosome 13q and containing two contiguous RTK genes, FLT1 and FLT3. The former has recently been shown to encode a RTK of a new class while the latter codes for a hematopoietic receptor closely related to the products of the FMS and KIT genes. The physical linkage is also evidenced in mouse, where the two genes appear to lie within a 350 kb Mlu I fragment, on mouse chromosome 5. |
