| First Author | Laval SH | Year | 1993 |
| Journal | Mamm Genome | Volume | 4 |
| Issue | 2 | Pages | 119-23 |
| PubMed ID | 8431636 | Mgi Jnum | J:3887 |
| Mgi Id | MGI:52392 | Doi | 10.1007/BF00290437 |
| Citation | Laval SH, et al. (1993) Partial inversion of gene order within a homologous segment on the X chromosome. Mamm Genome 4(2):119-23 |
| abstractText | The locus for the erthyroid transcription factor, GATA1, has been positioned in the small interval between DXS255 and TIMP on the proximal short arm of the human X Chromosome (Chr) by use of a partial human cDNA clone and a well-characterized somatic cell hybrid panel. Analysis of selected recombinants from 108 Mus musculus x Mus spretus backcross progeny with the same clone confirmed that the homologous murine locus (Gf-1) lies between Otc and the centromere of the mouse X Chr. These data imply that a partial inversion of gene order has occurred within the conserved segment that represents Xp21.1-Xp11.23 in human (CYBB-GATA1) and the proximal 6 cM of the mouse X Chr (Gf-1-Timp). Furthermore, they indicate that the mouse mutant scurfy and the human genetic disorder Wiskott-Aldrich syndrome, which have been mapped to the same regions as GATA1/Gf-1 in both species, may indeed be homologous disorders. |
