| First Author | McLaren A | Year | 1992 |
| Journal | Genet Res | Volume | 60 |
| Issue | 3 | Pages | 175-84 |
| PubMed ID | 1286802 | Mgi Jnum | J:24465 |
| Mgi Id | MGI:72205 | Doi | 10.1017/s0016672300030925 |
| Citation | McLaren A, et al. (1992) Recombination between the X and Y chromosomes and the Sxr region of the mouse. Genet Res 60(3):175-84 |
| abstractText | The Sxr (sex-reversed) region that carries a copy of the mouse Y chromosomal testis-determining gene can be attached to the distal end of either the Y or the X chromosome. During male meiosis, Sxr recombined freely between the X and Y chromosomes, with an estimated recombination frequency not significantly different from 50% in either direction. During female meiosis, Sxr recombined freely between the X chromosome to which it was attached and an X-autosome translocation. A male mouse carrying the original Sxra region on its Y chromosome, and the shorter Sxrb variant on the X, also showed 50% recombination between the sex chromosomes. Evidence of unequal crossing-over between the two Sxr regions was obtained: using five markers deleted from Sxrb, 3 variant Sxr regions were detected in 159 progeny (1.9%). Four other variants (one from the original cross and three from later generations) were presumed to have been derived from illegitimate pairing and crossing-over between Sxrb and the homologous region on the short arm of the Y chromosome. The generation of new variants throws light on the arrangement of gene loci and other markers within the short arm of the mouse Y chromosome. |
