| First Author | Palmieri SL | Year | 1992 |
| Journal | Mech Dev | Volume | 39 |
| Issue | 3 | Pages | 181-91 |
| PubMed ID | 1292572 | Mgi Jnum | J:3676 |
| Mgi Id | MGI:52185 | Doi | 10.1016/0925-4773(92)90045-l |
| Citation | Palmieri SL, et al. (1992) Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech Dev 39(3):181-91 |
| abstractText | We examined the expression of platelet-derived growth factor (PDGF)-A and the PDGF alpha-receptor in pre-implantation and early post-implantation mouse embryos. At two-cell and blastocyst stages, all cells express mRNA and protein for both ligand and receptor. In contrast, early post-implantation embryos express PDGF-A chain mRNA in both embryonic ectoderm and in the ectoderm lining the ectoplacental cavity, while mRNA for PDGF alpha-receptor is localized to the mesoderm layers of both embryonic and extra-embryonic membranes. At days 3.5 and 7.5, receptors are demonstrably functional in response to exogenous PDGF-AA. We propose that chronic autostimulation of PDGF alpha-receptors occurs in pre-implantation embryos, whereas, following implantation, early mesoderm development is dependent on stimulation by ectodermally produced PDGF-A. |
