| First Author | Watrin F | Year | 1993 |
| Journal | Dev Biol | Volume | 156 |
| Issue | 1 | Pages | 136-45 |
| PubMed ID | 7680626 | Mgi Jnum | J:4189 |
| Mgi Id | MGI:52688 | Doi | 10.1006/dbio.1993.1064 |
| Citation | Watrin F, et al. (1993) Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene. Dev Biol 156(1):136-45 |
| abstractText | A possible correlation between the structural organization of homeobox-containing genes and their cell-specific expression was examined in studies determining similarities and differences in the expression patterns of orthologues and paralogues of the murine Hox-1.4 gene. We first compared the expression pattern of members of the Hox-1.4 subfamily, Hox-2.6 and Hox-4.2, in the adult mouse testis. Although these three evolutionarily related genes exhibited similar anterior limits of expression in the embryonic central nervous system, their cellular specificity of expression was very different in the adult testis. Hox-1.4 was abundantly expressed only in the germ cells; Hox-2.6 was expressed at very low levels in both spermatogenic cells and somatic cells; and Hox-4.2 transcripts appeared to be restricted to the somatic cells. We next analyzed the expression of several of the Hox-1.4 orthologues in the mouse testis to determine if other members of the Hox-1 cluster are involved in the male germ cell differentiation pathway. We showed that the two adjacent genes of Hox-1.4, Hox-1.3 and Hox-1.5, are expressed in the germ line but at lower levels. Further, both Hox-1.3 and Hox-1.4 produced unique, germ line-specific transcripts as compared to other adult tissues and the Day 12.5 embryo. |
