| First Author | Iwai SA | Year | 1993 |
| Journal | Exp Cell Res | Volume | 205 |
| Issue | 1 | Pages | 39-43 |
| PubMed ID | 8453995 | Mgi Jnum | J:4178 |
| Mgi Id | MGI:52677 | Doi | 10.1006/excr.1993.1055 |
| Citation | Iwai SA, et al. (1993) Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. Exp Cell Res 205(1):39-43 |
| abstractText | To obtain information on the mechanism of teratocarcinoma cell differentiation, the expression of genes having a specific role in gene regulation was examined using three different methods of inducing differentiation: drug treatments with retinoic acid (RA) and sodium butyrate, and a genetic approach using ts mutants. The RAR-beta and MK genes were induced specifically by RA treatment, which indicates that these two genes are solely RA responsive. By contrast, a change in c-jun, Hox1.6, and Oct-3 gene expression was observed in all three methods of F9 cell differentiation. These findings suggest that these three genes, whether down-or up-regulated, play an important and key role during teratocarcinoma cell differentiation. |
