| First Author | Abe-Dohmae S | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 191 |
| Issue | 3 | Pages | 915-21 |
| PubMed ID | 8466531 | Mgi Jnum | J:34582 |
| Mgi Id | MGI:82037 | Doi | 10.1006/bbrc.1993.1304 |
| Citation | Abe-Dohmae S, et al. (1993) Bcl-2 gene is highly expressed during neurogenesis in the central nervous system. Biochem Biophys Res Commun 191(3):915-21 |
| abstractText | An analytical method for quantitation of the RNA transcripts of murine bcl-2 gene was developed. The PCR products from bcl-2 alpha and bcl-2 beta mRNA were fluorometrically analyzed and their specific contents were calculated by the internal standard method. Both bcl-2 mRNAs in adult mice were transcribed at the highest level in the thymus and at a comparable level in the spleen. Aside from the immune system, the brain gave the most abundant levels of the bcl-2 mRNAs. The ratios of bcl-2 beta mRNA to bcl-2 alpha mRNA in the thymus and spleen were significantly higher than those in other tissues. During development of the brain, the bcl-2 alpha and bcl-2 beta mRNA levels were highest on embryonic day 15, and about two and three times higher than those of adult, respectively. The results suggest that the bcl-2 gene functions to regulate development and survival of neurons in the central nervous system. |
