First Author | Cooper P | Year | 1993 |
Journal | Genomics | Volume | 15 |
Issue | 3 | Pages | 570-5 |
PubMed ID | 8468051 | Mgi Jnum | J:4219 |
Mgi Id | MGI:52716 | Doi | 10.1006/geno.1993.1109 |
Citation | Cooper P, et al. (1993) Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus. Genomics 15(3):570-5 |
abstractText | A physical map encompassing approximately 2.0 megabases (Mb) in the region of the mouse X-inactivation center has been constructed. The map extends from the Gjb-1 locus to the Xist locus and demonstrates the order of probes inseparable by genetic analysis. The deduced locus order is as follows: Gjb-1, Ccg-1, DXCrc171, Rps4, Phka, DXCrc177, DXCrc318, Xist. Detailed physical mapping in the region between the Phka and Xist loci indicates the position of CpG-rich islands associated with the 5' end of genes. The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region. |