| First Author | Pisa P | Year | 1993 |
| Journal | Scand J Immunol | Volume | 37 |
| Issue | 4 | Pages | 529-32 |
| PubMed ID | 8469936 | Mgi Jnum | J:12236 |
| Mgi Id | MGI:60486 | Doi | 10.1111/j.1365-3083.1993.tb03330.x |
| Citation | Pisa P, et al. (1993) Activated natural killer cells suppress myelopoiesis in mice with severe combined immunodeficiency. Scand J Immunol 37(4):529-32 |
| abstractText | The in vivo effect of natural killer (NK) cell activation on autologous myelopoiesis was studied in an environment deficient of functional T and B cells. Administration of 3,6-bis[2-(Dimethylamino)-ethoxy]-9H-xanthen-9-one dihydrochloride) Tilorone) or recombinant interleukin-2 (rIL-2) to mice with severe combined immunodeficiency (C.B.-17 scid/scid) resulted in an increase in YAC-1 lysis by their splenocytes as well as bone marrow cells. Recombinant IL-2 furthermore led to a fivefold increase in the cellularity of the spleen. When assayed against human NK/lymphokine-activated killer (LAK) target, K562 cell line, the IL-2-activated mouse cells exhibited no cytotoxicity across the species barrier. Both agents induced a profound suppression of myelopoietic progenitor cells as measured in a 7-day granulocyte-macrophage colony forming cell (GM-CFC) assay. We conclude that the presence of neither functional T nor B cells is necessary for NK cells to mediate inhibition of myelopoiesis in the autologous host. |
