| First Author | Li HS | Year | 1993 |
| Journal | Audiology | Volume | 32 |
| Issue | 3 | Pages | 195-204 |
| PubMed ID | 8489480 | Mgi Jnum | J:14501 |
| Mgi Id | MGI:62668 | Doi | 10.3109/00206099309072935 |
| Citation | Li HS, et al. (1993) Influence of age on noise-induced permanent threshold shifts in CBA/Ca and C57BL/6J mice. Audiology 32(3):195-204 |
| abstractText | Two inbred strains of mice, CBA/Ca (showing a moderate hearing loss with onset late in life) and C57BL/6J (undergoing spontaneous auditory degeneration with onset during young adulthood), were exposed to a broad-band noise of 120 dB SPL (2-7 kHz) for 5 min at 1,2,3,6 or 12 (only for CBA) months of age. Permanent threshold shifts (PTS) were determined by recording auditory brainstem response (ABR) 1 month after exposure. C57 mice were more severely affected by acoustic trauma than age-matched CBA mice. With increasing age, susceptibility to PTS decreased in CBA mice but remained constant in C57 mice. Results indicate that the auditory system of CBA mice undergoes a progressive resistance to noise damage, whereas the persistent high susceptibility to acoustic trauma in C57 mice may be related to their genetic predisposition to rapid auditory degeneration. |
