| First Author | Zemel S | Year | 1992 |
| Journal | Nat Genet | Volume | 2 |
| Issue | 1 | Pages | 61-5 |
| PubMed ID | 1303252 | Mgi Jnum | J:2189 |
| Mgi Id | MGI:50713 | Doi | 10.1038/ng0992-61 |
| Citation | Zemel S, et al. (1992) Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nat Genet 2(1):61-5 |
| abstractText | Parental imprinting is a phenomenon in mammals whereby the maternal and paternal alleles of a gene are differentially expressed. Three murine genes have been shown to display this type of allele-specific expression. Two of them, insulin-like growth factor-2 (Igf-2) and H19, map to the distal end of mouse chromosome 7, but are imprinted in opposite directions. Pulsed-field gel electrophoresis and large-fragment DNA cloning were utilized to establish a physical map that includes H19 and Igf-2. Igf-2 lies approximately 90 kilobases of DNA 5' to H19, in the same transcriptional orientation. This physical proximity is conserved in humans, based on pulsed-field gel analysis. We conclude that H19 and Igf-2 constitute an imprinted domain. |
