| First Author | McKenzie AN | Year | 1993 |
| Journal | J Immunol | Volume | 150 |
| Issue | 12 | Pages | 5436-44 |
| PubMed ID | 8099936 | Mgi Jnum | J:12611 |
| Mgi Id | MGI:60852 | Doi | 10.4049/jimmunol.150.12.5436 |
| Citation | McKenzie AN, et al. (1993) Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol 150(12):5436-44 |
| abstractText | The genomic structure of the recently described cytokine IL-13 has been determined for both human and mouse genes. The nucleotide sequence of a 4.6-kb DNA segment of the human gene is described. The human IL-13 gene (IL13) occurs as a single copy in the haploid genome and maps to human chromosome 5. A 4.3-kb DNA fragment of the mouse IL-13 gene (IL13) has been sequenced and found to occur as a single copy, mapping to mouse chromosome 11. Intrachromosomal mapping studies revealed that both genes contain four exons and three introns and show a high degree of sequence identity throughout their length. Potential recognition sequences for transcription factors that are present in the 5'-flanking region and are conserved between both genes include IFN-responsive elements, binding sites for AP-1, AP-2 and AP-3, and NF-IL 6 site, and a TATA-like sequence. Both genes map to chromosomal locations adjacent to genes encoding other cytokines, including IL-3, GM-CSF, IL-5, and IL-4, suggesting that IL-13 is another member of this cytokine gene family that may have arisen by gene duplication. |
