| First Author | White HD | Year | 1993 |
| Journal | J Virol | Volume | 67 |
| Issue | 8 | Pages | 5045-50 |
| PubMed ID | 8101231 | Mgi Jnum | J:13251 |
| Mgi Id | MGI:61457 | Doi | 10.1128/jvi.67.8.5045-5050.1993 |
| Citation | White HD, et al. (1993) Molecular cloning of infectious ecotropic murine leukemia virus AK7 from an emv-14-positive AKXL-5 mouse and the resistance of AK7 to recognition by cytotoxic T lymphocytes. J Virol 67(8):5045-50 |
| abstractText | The AKXL-5 recombinant inbred mouse strain is positive for the endogenous ecotropic murine leukemia virus emv-14, the only emv present in its germ line. emv-14 is of particular interest because spleen cells expressing emv-14 virus escape recognition by anti-AKR/Gross virus-specific cytotoxic T lymphocytes. We report here the isolation and characterization of a replication-competent emv clone, pAK7, derived from an AKXL-5 mouse. This clone is novel in that it encodes a variant ecotropic murine leukemia virus that, when expressed in SC.Kb target cells, fails to be recognized efficiently by anti-AKR/Gross virus cytotoxic T lymphocytes. The pAK7 clone can therefore be used to further probe mechanisms of escape from cell-mediated immunity. |
