| First Author | Lane JR | Year | 1993 |
| Journal | J Immunol | Volume | 151 |
| Issue | 3 | Pages | 1682-90 |
| PubMed ID | 8335952 | Mgi Jnum | J:37914 |
| Mgi Id | MGI:85310 | Doi | 10.4049/jimmunol.151.3.1682 |
| Citation | Lane JR, et al. (1993) Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. J Immunol 151(3):1682-90 |
| abstractText | We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease. |
