| First Author | Pilder SH | Year | 1993 |
| Journal | Dev Biol | Volume | 159 |
| Issue | 2 | Pages | 631-42 |
| PubMed ID | 8405685 | Mgi Jnum | J:14817 |
| Mgi Id | MGI:62978 | Doi | 10.1006/dbio.1993.1270 |
| Citation | Pilder SH, et al. (1993) Hybrid sterility-6: a mouse t complex locus controlling sperm flagellar assembly and movement. Dev Biol 159(2):631-42 |
| abstractText | Mouse t haplotypes alter sperm differentiation, resulting in abnormal sperm movement and sterility. In previous studies, a locus responsible for hybrid sterility in the genus Mus,Hst-4, was mapped to the distal inversion of the t complex on chromosome 17. Here we report the identification and characterization of two additional hybrid sterility loci, Hst-5 and Hst-6, that map to the same inversion. We further show that an abnormality in sperm flagellar curvature deriving from interactions between t haplotypes and the M. spretus allele of Hst-6 is indistinguishable from one exhibited by sperm from mice carrying two t haplotypes. Additionally, we demonstrate that this latter phenotype maps to the distal inversion of t haplotypes. Morphological and functional studies of Hst-6 mutant sperm also imply that the product(s) of Hst-6 is a spermatogenic-specific protein, important for assembly and function of the sperm axoneme. Thus, Hst-6 provides direct access to the molecular basis of t haplotype-specific alterations in sperm function that emanate from the t complex distal inversion. |
