| First Author | Heyborne K | Year | 1993 |
| Journal | J Immunol | Volume | 151 |
| Issue | 9 | Pages | 4523-7 |
| PubMed ID | 8409415 | Mgi Jnum | J:15219 |
| Mgi Id | MGI:63348 | Doi | 10.4049/jimmunol.151.9.4523 |
| Citation | Heyborne K, et al. (1993) Evidence that murine V gamma 5 and V gamma 6 gamma delta-TCR+ lymphocytes are derived from a common distinct lineage. J Immunol 151(9):4523-7 |
| abstractText | Murine V gamma 5 and V gamma 6+ T lymphocytes develop sequentially in the thymus during fetal and newborn life, giving rise to intraepithelial lymphocytes of the epidermis and female reproductive tract. In analyzing a panel of gamma delta T cell hybridomas derived from various tissues, we found that all V gamma 6+ cells tested (n = 25) expressed V gamma 5-C gamma 1 mRNA, whereas none of a panel of V gamma 6- cells analyzed (n = 33) expressed this mRNA. V gamma 6 mRNA was rare in V gamma 5+ cells (1 of 9), and absent in all other gamma delta T cells (n = 10). These findings suggest that most, if not all, V gamma 6-TCR+ lymphocytes arise from precursor cells that have previously rearranged the V gamma 5 gene, and indicate that V gamma 5 and V gamma 6+ lymphocytes belong to a common, distinct lineage that does not give rise to other gamma delta T cells. |
