| First Author | Uchida K | Year | 1993 |
| Journal | Jikken Dobutsu | Volume | 42 |
| Issue | 4 | Pages | 555-63 |
| PubMed ID | 8253133 | Mgi Jnum | J:15538 |
| Mgi Id | MGI:63658 | Doi | 10.1538/expanim1978.42.4_555 |
| Citation | Uchida K, et al. (1993) [Early lesions of pancreatic islets in small-ob mice (C57BL/6J-ob/ob)]. Jikken Dobutsu 42(4):555-63 |
| abstractText | Pancreatic islets of C57BL/6J-ob mice were microscopically examined at the ages of 5, 13, and 21 days, to clarify the time of the increase in number of A-cells, which appears to lead to diabetic symptoms in Small-ob mice (C57BL/6J-ob/ob). The findings of islet in 5-day-old C57BL/6J-ob mice were the same as those of C57BL/6J-+/+ mice. At 13 days of age, changes in islet of C57BL/6J-ob mice were classified into 3 groups. They were no significant changes (putative normal), hypertrophic B-cells with clear cytoplasm (Ob mice), and an increase of A-cells (Small-ob mice), respectively. Electron microscopically, a tendency toward dilatation of endoplasmic reticulum was found in the hypertrophic B-cells. In the islets that had an increase in number of A-cells, only a few vacuoles, which were suggestive of degranulation, were found in the cytoplasm of B-cells, and premature secretory granules were seen in the A-cells. In part of the A-cells, development of rough-surfaced endoplasmic reticulum was also seen. Mild hypertrophy of the islets and the B-cells were observed in more non-diabetic Ob mice at the age of 21 days than non-obese mice at the same age, and only 2 of 6 mice had the increase in number of A-cells. In Small-ob mice, the increase in number of A-cells was more obvious than in the diabetic Ob mice, while other islet findings were similar to those of non-obese mice in extent.(ABSTRACT TRUNCATED AT 250 WORDS) |
