| First Author | Marusić-Galesić S | Year | 1993 |
| Journal | Eur J Immunol | Volume | 23 |
| Issue | 12 | Pages | 3115-9 |
| PubMed ID | 8258325 | Mgi Jnum | J:16155 |
| Mgi Id | MGI:64245 | Doi | 10.1002/eji.1830231211 |
| Citation | Marusic-Galesic S, et al. (1993) Increased number of cytotoxic T cells within CD4+8- T cells in beta 2-microglobulin, major histocompatibility complex class I-deficient mice. Eur J Immunol 23(12):3115-9 |
| abstractText | Targeted disruption of beta 2-microglobulin gene results in deficient major histocompatibility complex class I expression and failure to develop CD4-8+ T cells. Despite this, beta 2 M-/- mice reject skin grafts and cope with most viral infections tested. We asked whether CD4+8- cytotoxic T cells would play a role in compensating for the defect in CD4-8+ cytotoxic T cell function. We found that the cytotoxic activity against class II+ targets is significantly higher among CD4+8- T cells of beta 2M-/- than among those of beta 2M+/+ mice. In the limiting dilution experiment, we showed that the precursor frequency for the cytotoxic, CD4+8-, class II-specific T cells is at least fivefold higher in beta 2M-/- than in beta 2M+/+ mice. These results suggest that CD4+8- cytotoxic T cells could play a major role in carrying out cytotoxic function in beta 2M-/- mice. |
