| First Author | Ouafik LH | Year | 1993 |
| Journal | Genomics | Volume | 18 |
| Issue | 2 | Pages | 319-21 |
| PubMed ID | 8288234 | Mgi Jnum | J:15566 |
| Mgi Id | MGI:63683 | Doi | 10.1006/geno.1993.1471 |
| Citation | Ouafik LH, et al. (1993) Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21. Genomics 18(2):319-21 |
| abstractText | Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a multifunctional protein containing two enzymes that act sequentially to catalyze the alpha-amidation of neuroendocrine peptides. Southern blot analysis of human placental DNA demonstrated that PAM is encoded by a single gene. The chromosomal localization of the PAM gene was established using in situ hybridization. A 2.2-kb human PAM cDNA hybridized to human metaphase chromosomes revealed a significant clustering of silver grains over chromosome 5 bands q14-q21. The gene encoding another enzyme important in the post-translational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is localized in the same region (5q15-q21). |
