| First Author | Sleight BJ | Year | 1993 |
| Journal | Anticancer Res | Volume | 13 |
| Issue | 6A | Pages | 2031-6 |
| PubMed ID | 8297111 | Mgi Jnum | J:21696 |
| Mgi Id | MGI:66401 | Citation | Sleight BJ, et al. (1993) S-cells from a highly N-myc-amplified neuroblastoma are tumorigenic in nude mice. Anticancer Res 13(6A):2031-6 |
| abstractText | Some neuroblastoma tumors when cultured in vitro give rise to N (neuronal) and S (non-neuronal) cells, which differ in morphology, state of differentiation, and tumorigenicity. Previously, tumor-forming potential was shown to be characteristic of N cells but not S cells. We examined cultures of N and S cells derived from a well-characterized, N-myc-amplified human neuroblastoma cell line, NBL-W, to determine whether these N and S cells also show differential tumorigenicity in nude mice. N cells formed tumors in 94% of trials and S cells formed tumors in 56% of trials. Although S cell tumors had a longer lag phase prior to tumor development, when tumors developed, both N and S cell-derived tumors grew rapidly. These results suggest that S cells do not always represent a benign component of neuroblastomas. |
