| First Author | Hemmi S | Year | 1994 |
| Journal | Cell | Volume | 76 |
| Issue | 5 | Pages | 803-10 |
| PubMed ID | 8124717 | Mgi Jnum | J:17173 |
| Mgi Id | MGI:65224 | Doi | 10.1016/0092-8674(94)90355-7 |
| Citation | Hemmi S, et al. (1994) A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 76(5):803-10 |
| abstractText | Expression of the human interferon gamma receptor (IFN-gamma R) in mouse cells is not sufficient to confer biological responsiveness to human IFN-gamma and vice versa. An additional species-specific component is required for signal transduction. We identified this cofactor by expression cloning in simian COS cells stably transfected with the nonfunctional murine IFN-gamma R and a IFN-gamma-inducible reporter construct encoding the human Tac antigen (interleukin-2 receptor alpha chain, CD25). A cDNA clone was obtained that, upon stable transfection, rendered human HEp-2 cells expressing the murine IFN-gamma R fully responsive to murine IFN-gamma. This cDNA encodes a novel 332 amino acid type I transmembrane protein that belongs to the IFN receptor family and that we designate IFN-gamma R beta chain. |
