| First Author | Koda T | Year | 1994 |
| Journal | FEBS Lett | Volume | 342 |
| Issue | 1 | Pages | 71-5 |
| PubMed ID | 8143853 | Mgi Jnum | J:18534 |
| Mgi Id | MGI:66719 | Doi | 10.1016/0014-5793(94)80587-3 |
| Citation | Koda T, et al. (1994) Regulatory sequences required for hst-1 expression in embryonal carcinoma cells. FEBS Lett 342(1):71-5 |
| abstractText | The hst-1 gene, which is implicated in mammalian embryonic development and morphological transformation of NIH3T3 cells, is expressed in undifferentiated F9 cells, but not in differentiated F9 and other well-differentiated cells, such as PYS-2, NIH3T3 and HeLa cells. An octamer element present in the 3' untranslated region acts as an enhancer. Although Oct3 is down-regulated when F9 cells are differentiated, transient expression of Oct3 did not enhance the hst-1 promoter activity in HeLa, NIH3T3 or PYS-2 cells. Thus, the role of Oct3 on hst-1 expression remains elusive, and an additional transcription factor which interacts may regulate hst-1 transcription in association with Oct1, Oct3 or both. |
