| First Author | Everaerdt B | Year | 1994 |
| Journal | J Immunol | Volume | 152 |
| Issue | 10 | Pages | 5041-9 |
| PubMed ID | 8176222 | Mgi Jnum | J:18044 |
| Mgi Id | MGI:66065 | Doi | 10.4049/jimmunol.152.10.5041 |
| Citation | Everaerdt B, et al. (1994) Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice. J Immunol 152(10):5041-9 |
| abstractText | The possible role of induced IL-1 in a number of in vivo actions of TNF was investigated. We were particularly interested to know whether a species-specific induction of IL-1 might explain the important differences observed between murine TNF and human TNF in systems such as lethal shock and the induction of long lasting, high levels of circulating IL-6 in mice. We also studied the possible involvement of IL-1 in the sensitization to TNF observed in tumor-bearing mice or in combination with D(+)-galactosamine or RU38486, particularly because such sensitization results in the loss of species-specific differences between both TNF. Using a specific rIL-1R antagonist (IL-1ra), which inhibits the binding of IL-1 to the IL-1R type I, we were able to protect mice against a lethal murine TNF injection. However, the induction of high levels of circulating IL-6 by murine TNF was not affected, although IL-1ra almost completely blocked the induction of IL-6 by exogenously administered IL-1. Furthermore, the increased susceptibility of tumor-bearing mice to human TNF, relative to control mice, or the sensitization by co-administration of RU38486 or D(+)-galactosamine do not seem to be mediated by IL-1. |
