| First Author | Hilburger ME | Year | 1994 |
| Journal | Clin Exp Immunol | Volume | 96 |
| Issue | 2 | Pages | 225-9 |
| PubMed ID | 8187331 | Mgi Jnum | J:18547 |
| Mgi Id | MGI:66805 | Doi | 10.1111/j.1365-2249.1994.tb06546.x |
| Citation | Hilburger ME, et al. (1994) Antigen presentation by macrophages from bacille Calmette-Guerin (BCG)-resistant and -susceptible mice. Clin Exp Immunol 96(2):225-9 |
| abstractText | We have compared the antigen-presenting capacity of macrophages from congenic BALB/c.Bcgr and BALB/c.Bcgs mice that differentially express MHC class II glycoproteins. Several different criteria were used to evaluate the presentation of a protein antigen, ovalbumin (OVA), including limiting the concentration of antigen or the numbers of macrophages, and using both native OVA and OVA peptide 323-339. No differences in the capacity of macrophages from Bcgr and Bcgs mice to present antigen to a OVA-specific T cell hybridoma were found. Splenic macrophages from BCG-infected congenic mice also induced an equivalent amount of IL-2 production by the T cell hybridoma. The relationship of these findings to other differences that have been attributed to Bcg are discussed. |
