| First Author | Lee SK | Year | 1994 |
| Journal | EMBO J | Volume | 13 |
| Issue | 9 | Pages | 2167-76 |
| PubMed ID | 8187770 | Mgi Jnum | J:18193 |
| Mgi Id | MGI:66206 | Doi | 10.1002/j.1460-2075.1994.tb06493.x |
| Citation | Lee SK, et al. (1994) Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. EMBO J 13(9):2167-76 |
| abstractText | To characterize the function of the Ly-6A antigen in T cell activation, antisense Ly-6 RNA was expressed in a stably transfected antigen-specific T cell clone. Reduced Ly-6A expression results in inhibition of responses to antigen, anti-TCR (anti-T cell receptor) crosslinking and concanavalin A plus recombinant interleukin 1 and causes impairment of in vitro fyn tyrosine kinase activity. More substantial reduction of Ly-6A results in reduction of TCR expression. Analysis of mRNA species indicates that the reduction is specific for the TCR beta chain. These data demonstrate that Ly-6A may regulate TCR expression and may be involved in early events of T cell activation via regulation of fyn tyrosine kinase activity. |
