| First Author | Avruch J | Year | 1994 |
| Journal | Trends Biochem Sci | Volume | 19 |
| Issue | 7 | Pages | 279-83 |
| PubMed ID | 8048167 | Mgi Jnum | J:19273 |
| Mgi Id | MGI:67452 | Doi | 10.1016/0968-0004(94)90005-1 |
| Citation | Avruch J, et al. (1994) Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem Sci 19(7):279-83 |
| abstractText | The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division. |
