| First Author | Myers MG Jr | Year | 1994 |
| Journal | Trends Biochem Sci | Volume | 19 |
| Issue | 7 | Pages | 289-93 |
| PubMed ID | 8048169 | Mgi Jnum | J:19272 |
| Mgi Id | MGI:67451 | Doi | 10.1016/0968-0004(94)90007-8 |
| Citation | Myers MG Jr, et al. (1994) The IRS-1 signaling system. Trends Biochem Sci 19(7):289-93 |
| abstractText | Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family. |
