| First Author | Reeder RH | Year | 1994 |
| Journal | Mol Microbiol | Volume | 12 |
| Issue | 1 | Pages | 11-5 |
| PubMed ID | 8057832 | Mgi Jnum | J:20760 |
| Mgi Id | MGI:68830 | Doi | 10.1111/j.1365-2958.1994.tb00989.x |
| Citation | Reeder RH, et al. (1994) The mechanism of transcription termination by RNA polymerase I. Mol Microbiol 12(1):11-5 |
| abstractText | Eukaryotic ribosomal gene transcription units are bordered at their 3' ends by short DNA sequences which specify site-specific termination by RNA polymerase I (polI). PolI terminators from yeast through to mammals appear to follow similar rules: they contain a site for a sequence-specific DNA-binding protein; they function only in one orientation; 3' ends are formed upstream of the binding site; and 5' flanking sequences influence the position and efficiency of 3' end formation. Recent progress in understanding the mechanism of RNA chain elongation by other polymerases suggests a model for polI termination in which termination is seen as one of the several outcomes possible when a polymerase encounters a pause site. |
