| First Author | McMenamin C | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5180 | Pages | 1869-71 |
| PubMed ID | 7916481 | Mgi Jnum | J:30908 |
| Mgi Id | MGI:78192 | Doi | 10.1126/science.7916481 |
| Citation | McMenamin C, et al. (1994) Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science 265(5180):1869-71 |
| abstractText | Indirect evidence implicates gamma delta T cells in the cross-regulation of CD4 alpha beta T cell responses. Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without affecting parallel IgG responses. Challenge of these gamma delta T cells in vitro with specific antigen resulted in production of high levels of interferon gamma. The effects of the gamma delta T cells may be mediated by direct inhibition of OVA-specific CD4+ TH2 cell proliferation or selection for specific CD4 TH2 cells. |
