| First Author | Clarke AR | Year | 1994 |
| Journal | Curr Opin Genet Dev | Volume | 4 |
| Issue | 3 | Pages | 453-60 |
| PubMed ID | 7919924 | Mgi Jnum | J:22005 |
| Mgi Id | MGI:69900 | Doi | 10.1016/0959-437x(94)90035-3 |
| Citation | Clarke AR (1994) Murine genetic models of human disease. Curr Opin Genet Dev 4(3):453-60 |
| abstractText | Until recently, good animal models of human disease have been available only in limited numbers, largely because of technical difficulties associated with transgenesis. As a consequence of recent rapid advances principally, but not exclusively, focused around the use of embryonic stem cells, it is now theoretically possible to model the genetic lesion underlying any human disease in the mouse. This has led not only to a better understanding of complex disease processes, such as those associated with malignancy, but, as in the cases of cystic fibrosis and duchenne muscular dystrophy, is now allowing the development of novel therapy regimes. |
