| First Author | Garside P | Year | 1994 |
| Journal | Immunology | Volume | 82 |
| Issue | 2 | Pages | 211-4 |
| PubMed ID | 7927491 | Mgi Jnum | J:18744 |
| Mgi Id | MGI:66983 | Citation | Garside P, et al. (1994) Differential cytokine production associated with distinct phases of murine graft-versus-host reaction. Immunology 82(2):211-4 |
| abstractText | Previous studies which demonstrated that cytokines such as interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are essential for the development of graft-versus-host reaction (GvHR) did not establish whether the individual cytokines were responsible for distinct features of the disease. In this report, we show that IFN-gamma production is associated with the early proliferative phase of the disease, whereas the late, destructive phase correlates with production of TNF-alpha. These studies may assist in the development of specific immunotherapies aimed at individual aspects of immunologically mediated disease. |
