| First Author | Wilton SD | Year | 1995 |
| Journal | Cytogenet Cell Genet | Volume | 68 |
| Issue | 1-2 | Pages | 122-4 |
| PubMed ID | 7956350 | Mgi Jnum | J:21770 |
| Mgi Id | MGI:69684 | Doi | 10.1159/000133905 |
| Citation | Wilton SD, et al. (1995) Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by fluorescence in situ hybridisation. Cytogenet Cell Genet 68(1-2):122-4 |
| abstractText | The human tropomyosin 3 (TPM3) gene was previously localized to chromosome 1. The non-muscle isoform of the TPM3 gene product becomes fused to a gene product from the tyrosine kinase receptor gene (NTRK1), previously localized to 1q23-->q24, to generate an active oncogene. Two sequence tagged sites spanning three exons and two introns in the carboxy coding region of the gene were used to localize TPM3 to 1q22-->q23 by fluorescence in situ hybridization. This localization now places the NTRK1 and TPM3 genes in close proximity, so that a gene fusion rearrangement would not be cytologically detected. The 1q22-->q23 localization of TPM3 is within the NEM1 locus associated with autosomal dominant nemaline myopathy, making TPM3 a candidate for this disorder. |
