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Publication : Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.

First Author  Mandich P Year  1994
Journal  Genomics Volume  22
Issue  1 Pages  216-8
PubMed ID  7959773 Mgi Jnum  J:23426
Mgi Id  MGI:71570 Doi  10.1006/geno.1994.1366
Citation  Mandich P, et al. (1994) Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Genomics 22(1):216-8
abstractText  The N-methyl-D-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N-methyl-D-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids.
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