| First Author | Williams AE | Year | 1994 |
| Journal | Brain Res | Volume | 654 |
| Issue | 2 | Pages | 200-6 |
| PubMed ID | 7987669 | Mgi Jnum | J:19779 |
| Mgi Id | MGI:67911 | Doi | 10.1016/0006-8993(94)90480-4 |
| Citation | Williams AE, et al. (1994) Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice. Brain Res 654(2):200-6 |
| abstractText | The presence of cytokines, prostaglandins and lipocortin-1 was investigated in terminally affected mice in two models of scrapie. There was marked induction of glial interleukin-1 beta, tumour necrosis factor alpha, prostaglandin E2, prostaglandin F2 alpha and lipocortin-1 immunoreactivity in those areas of the brain showing the characteristic vacuolation of scrapie. A comparison of these staining patterns with those of GFAP and F4/80 showed that their expression occurred predominantly in astrocytes. It is possible that cytokines play a significant role in the pathogenesis of neurodegeneration in scrapie. |
