| First Author | Sun XH | Year | 1994 |
| Journal | Cell | Volume | 79 |
| Issue | 5 | Pages | 893-900 |
| PubMed ID | 8001126 | Mgi Jnum | J:21936 |
| Mgi Id | MGI:69836 | Doi | 10.1016/0092-8674(94)90078-7 |
| Citation | Sun XH (1994) Constitutive expression of the Id1 gene impairs mouse B cell development [see comments]. Cell 79(5):893-900 |
| abstractText | The Id proteins are inhibitors of the basic-helix-loop-helix (bHLH) transcription factors. In the B cell lineage, the Id1 and Id2 genes are expressed in pro-B cells and down-regulated during differentiation. To determine the role of bHLH proteins and the significance of down-regulation of Id genes in B cell development, transgenic mice constitutively expressing the Id1 gene were generated. Their phenotype suggests that B cell development is impaired at an early stage. Primarily, these mice have few B220+ IgM+ mature B or B220+ CD43- pre-B cells in the bone marrow, reduced frequencies of V(D)J and V kappa J kappa recombination of the immunoglobulin loci, and lower expression levels of the immunoglobulin, RAG-1, RAG-2, and lambda 5 genes. |
