| First Author | Chalepakis G | Year | 1994 |
| Journal | Proc Natl Acad Sci U S A | Volume | 91 |
| Issue | 26 | Pages | 12745-9 |
| PubMed ID | 7809114 | Mgi Jnum | J:22078 |
| Mgi Id | MGI:69971 | Doi | 10.1073/pnas.91.26.12745 |
| Citation | Chalepakis G, et al. (1994) Pax-3 contains domains for transcription activation and transcription inhibition. Proc Natl Acad Sci U S A 91(26):12745-9 |
| abstractText | Pax-3 is a member of the Pax family of transcription factors involved in transcriptional control events during embryonic development. Here we report a functional dissection of the Pax-3 protein and describe the protein domains which are responsible for different activities. A transcription inhibition activity is located in the first 90 N-terminal amino acids and includes part of the paired domain. Furthermore, the C terminus of Pax-3 is able to confer transcriptional activation of basal promoters. Pax-3 can utilize both transcription modulating functions and activates transcription over a narrow range of protein concentration in the presence of promoter elements containing functional binding sites. |
