| First Author | Hartmann U | Year | 1994 |
| Journal | Cell Adhes Commun | Volume | 2 |
| Issue | 4 | Pages | 287-98 |
| PubMed ID | 7820532 | Mgi Jnum | J:20948 |
| Mgi Id | MGI:69003 | Doi | 10.3109/15419069409014204 |
| Citation | Hartmann U, et al. (1994) Ectopic expression of NCAM in mouse fibroblasts stimulates self-aggregation, and promotes integration into primary cerebellum cell aggregates. Cell Adhes Commun 2(4):287-98 |
| abstractText | We have undertaken aggregation experiments using mouse LMTK(-)-fibroblasts transfected with various isotypes of the neural cell adhesion molecule, NCAM. We found that self-aggregation of NCAM-positive fibroblasts is enhanced compared to control-transfected cells. The aggregation properties are partly dependent on the expressed NCAM isotype. Fibroblasts expressing a NCAM 140 isotype with exons a3 and pi were further tested in primary cerebellum cell re-aggregation experiments. While control-transfected fibroblasts could not be found in forming aggregates, fibroblasts ectopically expressing NCAM were integrated into neural cell aggregates. Time-lapse photography indicated that the nascent primary cell aggregates actively participated in the integration process by migration and attachment to nearby NCAM-positive fibroblasts. |
