| First Author | Smith RM | Year | 1994 |
| Journal | Immunology | Volume | 83 |
| Issue | 1 | Pages | 1-8 |
| PubMed ID | 7821954 | Mgi Jnum | J:20349 |
| Mgi Id | MGI:68445 | Citation | Smith RM, et al. (1994) Anti-class II MHC antibodies prevent and treat EAE without APC depletion. Immunology 83(1):1-8 |
| abstractText | We have demonstrated that a murine IgG1 anti-class II major histocompatibility complex (MHC) antibody (OX6) is able both to prevent and treat experimental autoimmune encephalomyelitis (EAE) in the Biozzi AB/H mouse. We have confirmed that this antibody is poorly cytotoxic, allowing mechanisms of action other than depletion of antigen-presenting cells (APC) to be assessed. Despite its effect on disease, OX6 administration does not prevent priming of T cells in the draining lymph node, implying an alternative mechanism for regulation of the autoimmune disease process. |
