| First Author | Kraus C | Year | 1994 |
| Journal | Genomics | Volume | 23 |
| Issue | 1 | Pages | 272-4 |
| PubMed ID | 7829088 | Mgi Jnum | J:24461 |
| Mgi Id | MGI:72201 | Doi | 10.1006/geno.1994.1493 |
| Citation | Kraus C, et al. (1994) Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics 23(1):272-4 |
| abstractText | The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-catenin sequences were selected on the basis of homology to exon 4 of the Drosophila armadillo gene. Analysis of a panel of somatic cell hybrids confirmed the localization of beta-catenin on human chromosome 3. Furthermore, exclusion mapping of three hybrids carrying defined fragments of the short arm of human chromosome 3 allowed us to determine the position of the CTNNB1 locus close to the marker D3S2 in 3p21. |
