| First Author | Ogura T | Year | 1995 |
| Journal | Proc Natl Acad Sci U S A | Volume | 92 |
| Issue | 2 | Pages | 387-91 |
| PubMed ID | 7831296 | Mgi Jnum | J:23063 |
| Mgi Id | MGI:70787 | Doi | 10.1073/pnas.92.2.387 |
| Citation | Ogura T, et al. (1995) A retinoic acid-triggered cascade of HOXB1 gene activation. Proc Natl Acad Sci U S A 92(2):387-91 |
| abstractText | Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have identified an RA-responsive element in the promoter of HOXB1 gene composed of two functionally separable sites: (i) a DR-2 sequence, which is the direct target of the RA receptor retinoid X receptor heterodimer; and (ii) a motif for an RA-inducible and tissue-specific coactivator termed retinoid-inducible protein. Through neither enhancer alone is functional, this combined element strongly activates the HOXB1 promoter in a cell-specific and retinoid-dependent manner. Finally, this activation is potentiated by a proximal autoregulatory site for HOXB1 gene itself. These data define a tripartite cascade leading to the establishment of HOXB1 gene activation. |
